1 00:00:01,000 --> 00:00:05,440 Do you ever stop to contemplate the wonder of your body? 2 00:00:05,440 --> 00:00:06,680 No? 3 00:00:06,680 --> 00:00:08,320 No, neither do I. 4 00:00:08,320 --> 00:00:12,000 But, actually, it's the most complicated piece of engineering 5 00:00:12,000 --> 00:00:16,680 known to us, and it throws up some very puzzling questions. 6 00:00:16,680 --> 00:00:18,080 Why do I catch colds? 7 00:00:19,400 --> 00:00:21,480 Where does wind come from? 8 00:00:21,480 --> 00:00:25,000 And what will we look like in 1,000 years? 9 00:00:25,000 --> 00:00:27,480 For the answers, stick with me, 10 00:00:27,480 --> 00:00:32,920 as we've uncovered the Things You Need To Know about the human body. 11 00:00:32,920 --> 00:00:38,000 Right, let's get this show on the road, starting at the beginning... 12 00:00:38,000 --> 00:00:40,680 Daddy, where did I come from? 13 00:00:40,680 --> 00:00:44,400 So, your dad told you that he and your mum loved each other, 14 00:00:44,400 --> 00:00:46,520 and decided to have a baby. 15 00:00:47,680 --> 00:00:50,880 Actually, it was much more complicated than that. 16 00:00:52,320 --> 00:00:56,600 If your father was an average guy, about 280 million of his sperm 17 00:00:56,600 --> 00:00:59,560 entered the race to fertilise your mother's egg. 18 00:01:03,400 --> 00:01:06,640 They were blasted in at an impressive 28mph, 19 00:01:06,640 --> 00:01:09,920 but almost instantly, 210 million had dropped out. 20 00:01:12,000 --> 00:01:13,920 What happened? 21 00:01:15,600 --> 00:01:18,760 Well, up to 70% of human sperm is dodgy. 22 00:01:18,760 --> 00:01:21,280 Some have three tails. 23 00:01:21,280 --> 00:01:24,040 There are two-headed sperm chasing their tails, 24 00:01:24,040 --> 00:01:26,680 and others with no tails at all. 25 00:01:26,680 --> 00:01:30,840 Humans compare pretty badly with the animal kingdom. 26 00:01:30,840 --> 00:01:37,280 Let's compare me with a rat and a pig. 27 00:01:37,280 --> 00:01:41,200 100% of the rat's sperm will be strong swimmers 28 00:01:41,200 --> 00:01:44,600 compared with only about 30% of mine. 29 00:01:44,600 --> 00:01:47,960 And the pig will produce two pints of sperm, 30 00:01:47,960 --> 00:01:50,920 where as I will produce about a teaspoonful. 31 00:01:53,080 --> 00:01:57,200 Anyway, back to the sperm's voyage through your mother. 32 00:01:57,200 --> 00:02:03,040 Those that made it into her cervix found themselves in a sticky maze. 33 00:02:03,040 --> 00:02:05,920 This mucus protects a uterus from germs, 34 00:02:05,920 --> 00:02:09,240 but it's also a hostile environment for sperm. 35 00:02:09,240 --> 00:02:11,360 Most will never get through. 36 00:02:13,560 --> 00:02:18,920 The 100,000 that did then had to race across the uterus - 37 00:02:18,920 --> 00:02:20,680 an exhausting marathon. 38 00:02:22,000 --> 00:02:26,000 By the fallopian tubes, we're down to just 200, 39 00:02:26,000 --> 00:02:28,040 and half of them swim up the wrong tube. 40 00:02:29,160 --> 00:02:33,800 Meanwhile, the egg is only fertile for 12 to 24 hours. 41 00:02:33,800 --> 00:02:38,760 Chemicals in the female body encourage the sperm to keep swimming. 42 00:02:40,200 --> 00:02:43,520 As they near the egg, they turn up the wick and accelerate. 43 00:02:48,480 --> 00:02:51,520 But there can only be one winner. 44 00:02:51,520 --> 00:02:53,640 As one super-sperm enters the egg, 45 00:02:53,640 --> 00:02:57,200 a chemical message seals its surface shut. 46 00:02:59,400 --> 00:03:02,560 So, if you ever feel down, remember this - 47 00:03:02,560 --> 00:03:06,360 you are the product of an Olympian sperm. 48 00:03:06,360 --> 00:03:09,160 Your father's sperm and your mother's egg 49 00:03:09,160 --> 00:03:13,080 contained all the information needed to make you. 50 00:03:13,080 --> 00:03:17,480 We are all unique products of our parents' genetic codes. 51 00:03:17,480 --> 00:03:19,000 In which case... 52 00:03:19,000 --> 00:03:21,680 How did I get my granny's chin? 53 00:03:22,800 --> 00:03:27,680 Since way back when, families have argued about who the kids look like. 54 00:03:27,680 --> 00:03:30,240 So, it was a nasty shock for your parents 55 00:03:30,240 --> 00:03:34,280 when you were born with your granny's smooth, pointy chin, 56 00:03:34,280 --> 00:03:36,480 instead of their elegant clefts. 57 00:03:39,800 --> 00:03:42,200 Your DNA is to blame. 58 00:03:42,200 --> 00:03:47,600 In 1953, James Watson and Francis Crick discovered that DNA, 59 00:03:47,600 --> 00:03:50,200 or Deoxyribonucleic acid, 60 00:03:50,200 --> 00:03:53,480 is contained in a structure called the double helix. 61 00:03:53,480 --> 00:03:56,320 Lying at the centre of virtually all our cells. 62 00:03:58,200 --> 00:04:01,960 Within your DNA are around 23,000 genes, 63 00:04:01,960 --> 00:04:03,960 which you inherited in two packs - 64 00:04:03,960 --> 00:04:07,120 one from your mother, and one from your father. 65 00:04:08,760 --> 00:04:12,520 Your genes come in pairs, one from each parent. 66 00:04:13,800 --> 00:04:18,120 Some pairs are what's called dominant recessive. 67 00:04:18,120 --> 00:04:21,480 A dominant gene - like the one that causes a cleft chin - 68 00:04:21,480 --> 00:04:23,760 always trumps its recessive pair, 69 00:04:23,760 --> 00:04:26,840 making sure its characteristic is turned on. 70 00:04:29,720 --> 00:04:33,840 But hang on, if your parents both have dominant cleft chins, 71 00:04:33,840 --> 00:04:36,720 then how can yours be smooth? 72 00:04:36,720 --> 00:04:40,760 Well, actually, we only inherit half of each of our parents' genes. 73 00:04:40,760 --> 00:04:43,160 That's one gene from each of their pairs. 74 00:04:46,240 --> 00:04:50,840 So we get half of our mum's genes and half of our dad's, 75 00:04:50,840 --> 00:04:56,640 so it must follow that we get a quarter of each of our grandparents'. 76 00:04:56,640 --> 00:04:59,280 Now here comes the important bit - 77 00:04:59,280 --> 00:05:02,080 genes passed down from our grandparents 78 00:05:02,080 --> 00:05:08,600 may be turned off in our parents, but turned on again in us. 79 00:05:08,600 --> 00:05:12,880 To see how this works, let's take a look at your family tree. 80 00:05:14,240 --> 00:05:17,840 Your dad got a dominant cleft gene from your grandfather, 81 00:05:17,840 --> 00:05:21,000 with a paired recessive gene from your grandmother. 82 00:05:22,280 --> 00:05:24,480 The same is true for your mother. 83 00:05:26,040 --> 00:05:29,960 So, in both of them, the dominant cleft gene was switched on. 84 00:05:32,560 --> 00:05:35,920 The eggs and sperm your parents produce could only carry 85 00:05:35,920 --> 00:05:37,960 one gene from each pair. 86 00:05:40,320 --> 00:05:43,840 It just so happened that the egg and sperm that made you 87 00:05:43,840 --> 00:05:46,280 both got the recessive chin gene, 88 00:05:46,280 --> 00:05:50,080 so you could only get your granny's pointy, smooth chin. 89 00:05:52,840 --> 00:05:55,600 The genetic mix your family gave you is unique, 90 00:05:55,600 --> 00:05:59,960 but the genes themselves aren't uniquely yours. 91 00:05:59,960 --> 00:06:04,200 That's because DNA is the blueprint for all life, 92 00:06:04,200 --> 00:06:08,480 from bacteria to human beings. 93 00:06:08,480 --> 00:06:11,240 All your organs are made up of cells, 94 00:06:11,240 --> 00:06:16,480 instructed by the genes within them to work together to keep you alive. 95 00:06:16,480 --> 00:06:19,120 We share this basic method of staying alive 96 00:06:19,120 --> 00:06:23,400 with every animal, and plant, on earth. 97 00:06:24,400 --> 00:06:28,920 Which means you share 95% of your genes with rats, 98 00:06:28,920 --> 00:06:33,120 60% with chickens, 99 00:06:33,120 --> 00:06:35,520 and 50% with bananas. 100 00:06:36,720 --> 00:06:41,400 Not all your features are decided by a single gene. 101 00:06:41,400 --> 00:06:45,280 Genes are divided across structures called chromosomes, 102 00:06:45,280 --> 00:06:48,920 and your eye colour, for example, was created by genes 103 00:06:48,920 --> 00:06:52,600 from different chromosomes working together in harmony. 104 00:06:52,600 --> 00:06:57,800 Now, this is very complex science, but here is a simple question... 105 00:06:57,800 --> 00:07:01,360 How are you seeing this? 106 00:07:01,360 --> 00:07:02,680 In Ancient Greece, 107 00:07:02,680 --> 00:07:07,160 some people believed that eyes worked by projecting beams of light. 108 00:07:07,160 --> 00:07:09,720 This idea was knocked on the head 109 00:07:09,720 --> 00:07:12,840 by the 11th century scientist, Alhazen. 110 00:07:12,840 --> 00:07:16,640 He figured out that we see by the light entering our eyes. 111 00:07:18,600 --> 00:07:23,560 Objects reflect light rays which are focused on to the retina, 112 00:07:23,560 --> 00:07:27,600 a layer at the back of the eyeball that's packed with 125 million 113 00:07:27,600 --> 00:07:31,440 light receptor cells called cones and rods. 114 00:07:33,840 --> 00:07:38,840 It's the red, blue and green cone cells that give you colour vision. 115 00:07:38,840 --> 00:07:41,960 In total, we see ten million different shades. 116 00:07:43,080 --> 00:07:46,560 What's more, your eyes are perfectly positioned to give you 117 00:07:46,560 --> 00:07:49,480 two separate fields of vision. 118 00:07:49,480 --> 00:07:53,440 Each eye shows your brain the same object from a different angle, 119 00:07:53,440 --> 00:07:58,080 allowing you to see in 3D and judge distance and depth. 120 00:07:58,080 --> 00:08:02,000 Human eyes move at over 30 mph, 121 00:08:02,000 --> 00:08:06,320 giving you more information than the rest of your senses combined. 122 00:08:07,360 --> 00:08:09,560 Impressive, till the sun drops 123 00:08:10,200 --> 00:08:13,920 and human vision starts to look rather shoddy - 124 00:08:13,920 --> 00:08:16,720 something you'll have noticed if you stub your toe 125 00:08:16,720 --> 00:08:19,640 when you get up to go to the lavvy in the middle of the night, 126 00:08:19,640 --> 00:08:22,240 while your cat wanders around as if he owns the place. 127 00:08:22,240 --> 00:08:24,560 Your eyes are missing something. 128 00:08:24,560 --> 00:08:29,160 Line up a human, a cat, a sheep, a seal and a deer, 129 00:08:29,160 --> 00:08:32,560 and it's only human eyes that don't glint at night. 130 00:08:34,520 --> 00:08:39,280 That's because the others have some awesome night-vision technology - 131 00:08:40,360 --> 00:08:43,960 a layer of shiny cells called the tapetum lucidum. 132 00:08:46,680 --> 00:08:50,000 When just a tiny bit of light trickles into the eye, 133 00:08:50,000 --> 00:08:52,160 this layer reflects it back, 134 00:08:52,160 --> 00:08:57,040 giving the receptor cells a second chance to pick up the light. 135 00:08:57,040 --> 00:09:00,480 So, it's a myth that your cat sees in total darkness, 136 00:09:00,480 --> 00:09:03,960 but it can see in one-sixth of the light that you can. 137 00:09:09,840 --> 00:09:11,560 I love cats. 138 00:09:11,560 --> 00:09:13,920 It's a pity they don't really like me. 139 00:09:13,920 --> 00:09:16,680 Actually, they don't really like anybody, 140 00:09:16,680 --> 00:09:18,840 they just want some food. 141 00:09:18,840 --> 00:09:24,000 Food is what keeps your cells working and keeps you on the road. 142 00:09:24,000 --> 00:09:28,920 Cells need fuel - that's why we eat, and this can cause pollution. 143 00:09:28,920 --> 00:09:30,080 So... 144 00:09:30,080 --> 00:09:32,360 where does wind come from? 145 00:09:33,720 --> 00:09:38,480 You eat 2,000 to 3,000 calories a day. 146 00:09:38,480 --> 00:09:41,800 You also let loose up to two and half pints of wind. 147 00:09:43,560 --> 00:09:47,720 We're told the Emperor Claudius thought releasing wind so important, 148 00:09:47,720 --> 00:09:50,240 he encouraged it at banquets. 149 00:09:51,400 --> 00:09:55,200 He was right - it's an essential by-product of digestion. 150 00:09:58,240 --> 00:10:00,840 Within ten seconds of swallowing, 151 00:10:00,840 --> 00:10:04,560 your stomach is whisking your food into a liquid called chyme, 152 00:10:04,560 --> 00:10:07,240 which is pushed into your small intestine, 153 00:10:07,240 --> 00:10:09,720 where most of the goodness is absorbed. 154 00:10:13,920 --> 00:10:16,360 The small intestine is actually huge - 155 00:10:16,360 --> 00:10:19,840 a folded, 21-foot tube which, pressed flat, 156 00:10:19,840 --> 00:10:23,320 would be bigger than a tennis court. 157 00:10:24,880 --> 00:10:28,440 So, while you're busy sipping coffee after your dinner, 158 00:10:28,440 --> 00:10:32,880 your stomach is already churning your shepherd's pie up into a soup, 159 00:10:32,880 --> 00:10:35,560 which your small intestine can break down 160 00:10:35,560 --> 00:10:38,280 into nutrients your cells can use. 161 00:10:38,280 --> 00:10:39,800 Unfortunately... 162 00:10:39,800 --> 00:10:41,160 HE BREAKS WIND 163 00:10:41,160 --> 00:10:42,880 there are some leftovers. 164 00:10:42,880 --> 00:10:46,720 Two and a half pints of watery gruel. 165 00:10:46,720 --> 00:10:48,920 This is poured into your large intestine, 166 00:10:48,920 --> 00:10:54,600 home to billions of bacteria known as gut flora. 167 00:10:54,600 --> 00:10:58,600 These account for over two pounds of your body weight. 168 00:10:58,600 --> 00:11:01,680 To your bacteria, this gruel is a feast. 169 00:11:01,680 --> 00:11:05,520 As it pours in, they set to work digesting the plant fibres 170 00:11:05,520 --> 00:11:11,240 your small intestine can't and extracting vitamins and fatty acids. 171 00:11:11,240 --> 00:11:15,760 This vital work produces gas, including carbon dioxide, 172 00:11:15,760 --> 00:11:20,200 hydrogen, methane and the odorous hydrogen sulphide... 173 00:11:21,760 --> 00:11:25,760 which builds up in your large intestine, along with solid waste, 174 00:11:25,760 --> 00:11:30,720 up to 50% of which is dead bacteria and cells from your own body. 175 00:11:34,280 --> 00:11:36,800 Your intestinal muscles then squeeze 176 00:11:36,800 --> 00:11:40,640 to create a zone of high pressure that moves the gas and waste 177 00:11:40,640 --> 00:11:42,440 down towards your rectum... 178 00:11:44,720 --> 00:11:48,160 forcing you to let out wind around ten times a day. 179 00:11:50,200 --> 00:11:51,720 FART SOUNDS 180 00:11:51,720 --> 00:11:56,120 Embarrassing when not expected, but at least you can do it on the move, 181 00:11:56,120 --> 00:11:59,280 whereas getting rid of solid waste takes time. 182 00:11:59,280 --> 00:12:02,280 According to a recent survey, by the end of our lives 183 00:12:02,280 --> 00:12:05,360 we'll have spent 90 days sitting on the lavvy... 184 00:12:05,360 --> 00:12:07,120 STRAINING NOISES 185 00:12:08,480 --> 00:12:14,080 ..giving us plenty of opportunities for a nice quiet read. 186 00:12:14,080 --> 00:12:18,360 Now, if I'm Mr Average, I'm made up of two stone of protein, 187 00:12:18,360 --> 00:12:22,600 two stone of fat, and around eleven pints of blood. 188 00:12:22,600 --> 00:12:24,480 Sounds disgusting. 189 00:12:24,480 --> 00:12:26,000 But to other life forms, 190 00:12:26,000 --> 00:12:29,920 our bodies are actually an irresistible all-day buffet, 191 00:12:29,920 --> 00:12:32,360 which begs a rather unusual question... 192 00:12:32,360 --> 00:12:36,800 Is there life on me? 193 00:12:36,800 --> 00:12:42,280 As the proud owner of a human body, you see yourself as an individual. 194 00:12:42,280 --> 00:12:44,280 But, if an alien examined you, 195 00:12:44,280 --> 00:12:49,880 he'd see a walking zoo of bacteria and parasites. 196 00:12:49,880 --> 00:12:53,840 Your bacteria outnumber your cells ten to one. 197 00:12:53,840 --> 00:12:57,400 Numerically, you're 90% microbe. 198 00:12:57,400 --> 00:13:01,840 You house around 500 species in your gut, 199 00:13:01,840 --> 00:13:05,960 128 in your lungs, 200 00:13:05,960 --> 00:13:08,960 and up to 200 in your mouth. 201 00:13:08,960 --> 00:13:11,160 Gross! 202 00:13:11,160 --> 00:13:15,800 But as we've seen in the intestine, some bacteria are vital. 203 00:13:15,800 --> 00:13:18,000 More than you can say for... 204 00:13:18,000 --> 00:13:19,640 parasites. 205 00:13:19,640 --> 00:13:25,200 At some point, face mites will almost certainly feed off your skin. 206 00:13:25,200 --> 00:13:29,080 Right now, they may diving down into your follicles, 207 00:13:29,080 --> 00:13:33,720 using their needle-like mouths to hoover up some of the eight pounds 208 00:13:33,720 --> 00:13:36,720 of skin cells you lose every year. 209 00:13:36,720 --> 00:13:38,720 SOUND OF A VACUUM CLEANER 210 00:13:38,720 --> 00:13:40,760 Pull the plug, it's eating me alive! 211 00:13:40,760 --> 00:13:46,560 Scary, but better than feeding bloodsucking bedbugs. 212 00:13:46,560 --> 00:13:50,000 Vampire fiction is, of course, all the rage, 213 00:13:50,000 --> 00:13:54,480 but the real twilight bloodsuckers are rather less romantic. 214 00:13:54,480 --> 00:13:58,720 A few years ago, we believed we had the bedbug beaten. 215 00:13:58,720 --> 00:14:03,720 But now, all across the world, the bedbug is back. 216 00:14:03,720 --> 00:14:09,520 Bedbugs use their six legs to scuttle out as you sleep. 217 00:14:09,520 --> 00:14:12,800 One feeding tube administers anaesthetic 218 00:14:12,800 --> 00:14:17,000 to keep you in the land of nod, while the other sucks your blood. 219 00:14:19,400 --> 00:14:20,960 Nasty. 220 00:14:20,960 --> 00:14:24,960 But nowhere near as bad as hosting a tapeworm. 221 00:14:24,960 --> 00:14:29,640 The tapeworm gets in as larvae in undercooked meat. 222 00:14:29,640 --> 00:14:32,320 Once inside, it clings to your intestines, 223 00:14:32,320 --> 00:14:37,400 spending up to 25 years happily bathing in your undigested food. 224 00:14:39,160 --> 00:14:44,840 By absorbing your nutrients through its skin, it can grow up to 30 feet. 225 00:14:48,920 --> 00:14:51,720 With any luck you'll manage to avoid tapeworm, 226 00:14:51,720 --> 00:14:55,520 unless you're one of those blokes who believes he can do a barbecue. 227 00:14:55,520 --> 00:14:59,360 Viruses, on the other hand, are most definitely going to get you, 228 00:14:59,360 --> 00:15:03,840 and when they do, they will give you anything from a cold to Ebola. 229 00:15:03,840 --> 00:15:08,360 And yet, technically, viruses have no life of their own, 230 00:15:08,360 --> 00:15:10,840 so why do they cause so much trouble? 231 00:15:10,840 --> 00:15:12,200 More to the point... 232 00:15:12,200 --> 00:15:15,320 Why do I catch colds? 233 00:15:18,560 --> 00:15:20,960 See that guy with the blocked nose? 234 00:15:20,960 --> 00:15:26,240 When he sneezes, 40,000 droplets will fly twelve feet in the air, 235 00:15:26,240 --> 00:15:28,600 infecting up to 150 people. 236 00:15:28,600 --> 00:15:29,760 Ugh! 237 00:15:29,760 --> 00:15:31,000 You should have ducked. 238 00:15:32,280 --> 00:15:34,760 A cold virus just can't live without you. 239 00:15:34,760 --> 00:15:37,160 WOMAN SCREAMS 240 00:15:37,160 --> 00:15:38,600 With no cells of its own, 241 00:15:38,600 --> 00:15:41,280 it needs to take over your cells and replicate. 242 00:15:41,280 --> 00:15:43,400 Here's something to think about - 243 00:15:43,400 --> 00:15:48,480 the virus can only travel around inside a blob of mucus, 244 00:15:48,480 --> 00:15:51,360 and that means that when you catch a sniffle, 245 00:15:51,360 --> 00:15:54,320 someone else's snot has been up your nose. 246 00:15:54,320 --> 00:15:55,600 Anyway... 247 00:15:55,600 --> 00:16:00,480 your immune system is constantly on the prowl for attackers like these. 248 00:16:00,480 --> 00:16:04,440 If it wasn't, you could end up with fatal pneumonia. 249 00:16:06,040 --> 00:16:10,360 So, when it spots a viral invasion, it grabs a sample 250 00:16:10,360 --> 00:16:14,200 and takes it to the nearest lymph node, home of your killer T cells. 251 00:16:16,760 --> 00:16:20,320 Here, a T cell first identifies the invader, 252 00:16:20,320 --> 00:16:25,480 and then deploys an army of tailor-made immune cells to your nose. 253 00:16:28,520 --> 00:16:30,280 These provide specialist backup 254 00:16:30,280 --> 00:16:34,640 for the standard immune cells already fighting your cold. 255 00:16:35,880 --> 00:16:38,480 Your nose has become a battleground. 256 00:16:40,440 --> 00:16:43,760 Meanwhile, to stop infection spreading to your lungs, 257 00:16:43,760 --> 00:16:46,960 you're manufacturing a daily pint of mucus. 258 00:16:48,680 --> 00:16:53,920 This snot gives you a headache, while the virus irritates your nose, 259 00:16:53,920 --> 00:16:57,120 so you have to blow it around 45 times a day. 260 00:17:01,160 --> 00:17:05,200 Beating a cold takes you about seven days, 261 00:17:05,200 --> 00:17:08,160 and you'll catch about four a year. 262 00:17:09,360 --> 00:17:12,480 This is the golden age for the cold virus. 263 00:17:14,920 --> 00:17:18,360 It hops on planes with its human hosts, visits new cities, 264 00:17:18,360 --> 00:17:22,240 and finds hundreds of new homes with every sneeze. 265 00:17:25,640 --> 00:17:28,160 As it replicates, it mutates, 266 00:17:28,160 --> 00:17:32,480 so by next year it may be back in a different form. 267 00:17:32,480 --> 00:17:34,480 SNEEZING 268 00:17:34,480 --> 00:17:37,800 Children catch more colds than adults 269 00:17:37,800 --> 00:17:41,440 because their immune systems are less experienced. 270 00:17:41,440 --> 00:17:44,160 We also take ages to grow up - 271 00:17:44,160 --> 00:17:48,280 the human being is the only species with a long adolescence - 272 00:17:48,280 --> 00:17:53,160 and this life phase developed around 500,000 years ago, 273 00:17:53,160 --> 00:17:58,280 just before the human brain developed into its current large size. 274 00:17:58,280 --> 00:18:01,920 And all of this makes it much easier to answer our next question... 275 00:18:01,920 --> 00:18:05,040 Why are teenagers so moody? 276 00:18:06,160 --> 00:18:08,520 At around eight or nine, an alarm goes off 277 00:18:08,520 --> 00:18:10,840 in the hypothalamus region of the brain, 278 00:18:10,840 --> 00:18:14,400 waking up powerful hormones and triggering seismic changes, 279 00:18:14,400 --> 00:18:18,800 which eventually erupt as breasts, 280 00:18:18,800 --> 00:18:21,960 body hair, and bodily functions. 281 00:18:21,960 --> 00:18:23,040 GROANING 282 00:18:23,040 --> 00:18:26,480 Along with volcanic surges of temper, 283 00:18:26,480 --> 00:18:30,640 which, until recently, were also put down to hormones. 284 00:18:30,640 --> 00:18:34,200 Now experts believe the brain is to blame. 285 00:18:34,200 --> 00:18:38,760 We used to think the human brain was mature by 18 months. 286 00:18:40,360 --> 00:18:41,520 Not any more. 287 00:18:41,520 --> 00:18:44,200 When scientists used magnetic resonance imaging 288 00:18:44,200 --> 00:18:46,720 to scan the brains of young adolescents, 289 00:18:46,720 --> 00:18:49,760 they discovered multiplying connections 290 00:18:49,760 --> 00:18:53,000 between the cells of the prefrontal cortex. 291 00:18:56,080 --> 00:18:58,320 That's the bit of the brain 292 00:18:58,320 --> 00:19:01,320 that makes decisions and controls emotion. 293 00:19:01,320 --> 00:19:04,000 So, what happens when we ask a teenage 294 00:19:04,000 --> 00:19:07,560 and an adult brain a straightforward question? 295 00:19:07,560 --> 00:19:12,760 The young brain's freshly grown connections really slow it down. 296 00:19:12,760 --> 00:19:16,680 The teenage brain - here's one we found earlier - 297 00:19:16,680 --> 00:19:20,320 finds it tough to control impulses and emotions, 298 00:19:20,320 --> 00:19:24,680 and this explains why teenagers think going out drinking 299 00:19:24,680 --> 00:19:28,600 with their mates is a viable alternative to, say, exam revision, 300 00:19:28,600 --> 00:19:31,520 and that it explains why they can't understand 301 00:19:31,520 --> 00:19:34,840 that this will upset their parents. 302 00:19:34,840 --> 00:19:38,720 Because research show that young adolescent brains struggle 303 00:19:38,720 --> 00:19:41,520 to read facial expressions. 304 00:19:41,520 --> 00:19:45,600 Thankfully, by adulthood, the troublesome extra connections are pruned. 305 00:19:47,520 --> 00:19:50,600 Mind you, hormones aren't entirely off the hook 306 00:19:50,600 --> 00:19:52,760 when it comes to teenage moods. 307 00:19:52,760 --> 00:19:58,200 Hormones produce female curves and male muscles, 308 00:19:58,200 --> 00:20:02,040 but also an oily substance called sebum, 309 00:20:02,040 --> 00:20:05,560 which means 80% of teenage skin suffers from... 310 00:20:07,120 --> 00:20:09,400 whiteheads, blackheads, 311 00:20:09,400 --> 00:20:11,440 yellow, pus-sy pimples, 312 00:20:11,440 --> 00:20:15,080 and, if they're really unlucky, bulging nodules. 313 00:20:15,080 --> 00:20:18,160 At the exact moment they want to look attractive, 314 00:20:18,160 --> 00:20:20,240 teenagers start resembling pizza. 315 00:20:20,240 --> 00:20:22,280 And if they do manage to get a date, 316 00:20:22,280 --> 00:20:25,160 their brains are so emotionally inept 317 00:20:25,160 --> 00:20:27,920 they're almost bound to mess it up. 318 00:20:27,920 --> 00:20:32,320 Teenagers can be forgiven for not being able to handle alcohol. 319 00:20:32,320 --> 00:20:35,320 Adults, you'd think, would know better, 320 00:20:35,320 --> 00:20:39,520 but I'm afraid we don't, because every day in Britain, 321 00:20:39,520 --> 00:20:45,000 500,000 of us go to work with a hangover. 322 00:20:45,000 --> 00:20:47,120 Although, mind you, it's not just us. 323 00:20:47,120 --> 00:20:49,560 Human beings have been boozing like mad 324 00:20:49,560 --> 00:20:52,040 for thousands and thousands of years, 325 00:20:52,040 --> 00:20:56,480 which gives my next question truly international significance. 326 00:20:57,680 --> 00:20:58,880 Mmm. 327 00:21:00,240 --> 00:21:04,400 Why am I hung-over? 328 00:21:04,400 --> 00:21:05,840 Headache? 329 00:21:05,840 --> 00:21:06,880 Dizziness? 330 00:21:06,880 --> 00:21:07,920 Nausea? 331 00:21:07,920 --> 00:21:10,320 The evidence suggests you drink alcohol. 332 00:21:10,320 --> 00:21:16,000 On average, we each sink more than a gallon of pure alcohol a year. 333 00:21:16,000 --> 00:21:20,520 Worldwide, this adds up to a trillion pints of beer, 334 00:21:20,520 --> 00:21:24,320 or 250 billion bottles of wine, 335 00:21:24,320 --> 00:21:26,680 or 100 billion bottles of vodka. 336 00:21:28,440 --> 00:21:33,160 To find out how it makes you feel so bad, we need to flash back. 337 00:21:33,160 --> 00:21:36,880 90 seconds after your first sip, the alcohol hit your brain, 338 00:21:36,880 --> 00:21:40,920 and interfered with your neurotransmitters, 339 00:21:40,920 --> 00:21:44,480 making you talkative and self-confident. 340 00:21:44,480 --> 00:21:48,160 By drink two, your inhibitions were really dropping. 341 00:21:48,160 --> 00:21:49,560 Back inside your brain, 342 00:21:49,560 --> 00:21:53,600 a chemical called vasopressin would normally be sending a signal 343 00:21:53,600 --> 00:21:57,320 to your kidneys, to tell them how much water take from your blood. 344 00:21:59,120 --> 00:22:01,640 Alcohol switches this chemical off. 345 00:22:02,960 --> 00:22:07,280 So, your kidneys started channelling most of the water to your bladder. 346 00:22:07,280 --> 00:22:13,120 For every drink, you expelled four times as much in urine. 347 00:22:13,120 --> 00:22:16,440 By now, you were also tired and emotional. 348 00:22:16,440 --> 00:22:20,720 Thankfully, someone took you home, where you crashed out. 349 00:22:20,720 --> 00:22:22,240 And slept really badly. 350 00:22:22,240 --> 00:22:26,800 That's because alcohol suppresses the production of glutamine, 351 00:22:26,800 --> 00:22:29,560 one of the body's natural stimulants. 352 00:22:29,560 --> 00:22:33,000 When you stopped drinking, production revved up again, 353 00:22:33,000 --> 00:22:36,520 so you spent the night tossing and turning. 354 00:22:36,520 --> 00:22:41,200 Overnight, your dehydrated liver had to process the alcohol toxins, 355 00:22:41,200 --> 00:22:44,320 so it stole water from your brain, which shrank 356 00:22:44,320 --> 00:22:48,320 and began to pull on the membranes attaching it to your skull. 357 00:22:48,320 --> 00:22:52,200 Which is why you just woke up with a pounding head, dry mouth, 358 00:22:52,200 --> 00:22:56,480 and nausea from the after-effects of the toxins. 359 00:22:56,480 --> 00:22:59,480 A hangover can last for up to 24 hours, 360 00:22:59,480 --> 00:23:04,400 giving you plenty of time to think about what you did last night. 361 00:23:04,400 --> 00:23:09,280 If you can face it, a cooked breakfast might help. 362 00:23:09,280 --> 00:23:11,040 But chances are you can't, 363 00:23:11,040 --> 00:23:14,920 so you'll just have to spend the day feeling like death. 364 00:23:14,920 --> 00:23:16,800 But then one day you'll be ill 365 00:23:16,800 --> 00:23:19,440 and your body won't be able to make you better, 366 00:23:19,440 --> 00:23:23,320 and that brings us to the greatest question in life... 367 00:23:23,320 --> 00:23:26,280 Why do I have to die? 368 00:23:26,280 --> 00:23:30,040 For most of history, human life has been dangerous and short. 369 00:23:30,040 --> 00:23:33,640 Natural selection favoured the genes that made you strong, 370 00:23:33,640 --> 00:23:36,600 not the ones that helped you get old. 371 00:23:36,600 --> 00:23:40,280 Our bodies still peak between 20 and 35. 372 00:23:40,280 --> 00:23:43,480 After that, it's a slippery slope to the grave. 373 00:23:45,280 --> 00:23:49,440 To find out why, scientists are investigating our cells. 374 00:23:49,440 --> 00:23:53,200 When you're young and healthy, your cells divide and replicate 375 00:23:53,200 --> 00:23:56,080 50 billion times every day. 376 00:23:56,080 --> 00:24:00,480 But each individual cell can only split 50 times. 377 00:24:00,480 --> 00:24:03,240 When it hits this magic number, it's retired. 378 00:24:06,040 --> 00:24:09,680 As you age, cell death starts to outpace cell birth. 379 00:24:11,360 --> 00:24:16,320 And ageing cells are more vulnerable to attackers. 380 00:24:16,320 --> 00:24:19,200 Amongst the worst are free radicals - 381 00:24:19,200 --> 00:24:22,440 unstable oxygen molecules which stabilize themselves 382 00:24:22,440 --> 00:24:25,040 by stealing electrons from your cells... 383 00:24:27,840 --> 00:24:32,880 inflicting damage that can cause diseases like cancer. 384 00:24:32,880 --> 00:24:34,800 Free radicals aren't the only problem - 385 00:24:35,440 --> 00:24:38,120 old cells just get tired. 386 00:24:38,120 --> 00:24:42,320 The elderly cell enlarges, and becomes less efficient 387 00:24:42,320 --> 00:24:45,640 at turning oxygen and nutrients into energy. 388 00:24:45,640 --> 00:24:48,200 A bit like a person, really. 389 00:24:48,200 --> 00:24:51,200 You can see the results of ageing in your skin. 390 00:24:51,200 --> 00:24:55,200 Inside your body, the same thing is going on. 391 00:24:55,200 --> 00:24:59,000 At 40, your nervous system becomes less co-ordinated, 392 00:24:59,000 --> 00:25:02,120 giving you heartburn and constipation. 393 00:25:02,120 --> 00:25:08,760 By 60, your eyes let in two-thirds less light than they did at 20. 394 00:25:08,760 --> 00:25:14,120 And at 85, your heart can only beat a fifth as fast as a 20-year-old's. 395 00:25:14,120 --> 00:25:15,840 At which point, well, 396 00:25:15,840 --> 00:25:20,280 you and your magnificent body are just about to hit journey's end. 397 00:25:21,440 --> 00:25:25,600 Although science is helping more of us to live to be old, 398 00:25:25,600 --> 00:25:28,600 humans have a natural lifespan. 399 00:25:28,600 --> 00:25:30,600 85 is about it, really, 400 00:25:30,600 --> 00:25:34,920 and conventional medicine isn't likely to extend this very much. 401 00:25:34,920 --> 00:25:39,360 But of course, medicine is becoming more and more unconventional, 402 00:25:39,360 --> 00:25:44,200 so for our descendants, life and death may be very different. 403 00:25:44,200 --> 00:25:48,720 So what will we look like in 1,000 years' time? 404 00:25:48,720 --> 00:25:53,680 Two million years ago, Homo habilis made stone tools. 405 00:25:53,680 --> 00:25:57,560 These days, Homo sapiens design computer chips. 406 00:25:57,560 --> 00:26:01,160 Next, we'll be taking charge of our own evolution. 407 00:26:01,160 --> 00:26:05,600 In 2008, scientists announced that they had taken a rat's heart, 408 00:26:05,600 --> 00:26:11,640 stripped it to its scaffolding, and re-seeded it with cardiac cells. 409 00:26:11,640 --> 00:26:15,000 Within four days, the cells were contracting. 410 00:26:15,000 --> 00:26:17,440 Within eight, they had begun to pump. 411 00:26:17,440 --> 00:26:21,600 This was a big step on the road to replacement organs. 412 00:26:22,680 --> 00:26:26,680 Also in the pipeline are eyes, lungs and limbs. 413 00:26:27,840 --> 00:26:30,600 This technology could make us immortal 414 00:26:30,600 --> 00:26:34,680 IF we can also work out how to regenerate our brains. 415 00:26:35,920 --> 00:26:38,160 But that will take a while, 416 00:26:38,160 --> 00:26:42,440 because the brain is a mind-bogglingly complex thing. 417 00:26:42,440 --> 00:26:46,200 Inside here there are a hundred billion cells, 418 00:26:46,200 --> 00:26:50,680 all communicating through tiny waves of electricity. 419 00:26:50,680 --> 00:26:54,400 And somewhere within all those cells and all those connections 420 00:26:54,400 --> 00:26:58,440 is the mind, the essence of you and me. 421 00:27:00,200 --> 00:27:05,480 Scientists are determined to unlock the mysteries of the mind. 422 00:27:05,480 --> 00:27:08,520 When they do, we may achieve not just immortality, 423 00:27:08,520 --> 00:27:11,840 but a higher intelligence than we can imagine. 424 00:27:11,840 --> 00:27:14,000 Here's how - 425 00:27:14,000 --> 00:27:17,040 in 2004, a computer chip was implanted 426 00:27:17,040 --> 00:27:20,240 into the brain of a paralysed man. 427 00:27:20,240 --> 00:27:23,680 When he wanted to watch TV, the chip read his thoughts, 428 00:27:23,680 --> 00:27:25,280 and switched the channels. 429 00:27:26,480 --> 00:27:30,840 By 2050, it's predicted that computer-brain interaction 430 00:27:30,840 --> 00:27:35,520 will be so advanced, that we'll use PCs to store our surplus memories. 431 00:27:36,840 --> 00:27:40,040 Beyond that, we'll aim to devise technology to merge 432 00:27:40,040 --> 00:27:44,440 the creativity of human thought with the speed of computers. 433 00:27:44,440 --> 00:27:48,160 So, while your descendants might choose to look human, 434 00:27:48,160 --> 00:27:51,440 inside they could be more machine than man. 435 00:27:54,160 --> 00:27:57,120 So, back to my first question - 436 00:27:57,120 --> 00:28:01,080 do you ever contemplate the wonder of your body? 437 00:28:01,080 --> 00:28:03,280 Well, we just have, 438 00:28:03,280 --> 00:28:05,760 and now I'm incredibly proud to own one, 439 00:28:05,760 --> 00:28:09,520 a marvellous vehicle in which to journey through life. 440 00:28:09,520 --> 00:28:12,280 And one day that journey may last forever, 441 00:28:12,280 --> 00:28:15,360 but I'm afraid you and I were born too early for that. 442 00:28:15,360 --> 00:28:18,920 All we can do is sit back and enjoy the rest of the ride. 443 00:28:44,720 --> 00:28:46,760 Subtitles by Red Bee Media Ltd 444 00:28:46,760 --> 00:28:48,800 E-mail subtitling@bbc.co.uk